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THR-β agonist 9

THR-β Agonist

THR-β agonist 9 is a highly selective agonist targeting the thyroid hormone receptor beta (THR-β), demonstrating an EC50 of 3.2 nM. This compound exhibits moderate selectivity, approximately 10-fold, and effectively activates multiple His435 mutations, including H435A, H435Y, and H435R, with activation capacities ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 is a valuable tool for investigating conditions such as dyslipidemia, metabolic dysfunction-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH).

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	2920045-74-3
Applications	THR-β Agonist
Formula	C₂₃H₁₈N₂O₆
Molecular Weight	418.40
SMILES	OC1=C(C(NCC(O)=O)=O)N=C(OC)C2=CC(OC3=CC=C4C(C=CC=C4)=C3)=CC=C21

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.