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Thymidine 5′-diphosphate

Pyrimidine Synthesis

Thymidine 5′-diphosphate (dTDP) serves as a critical intermediate in pyrimidine synthesis, acting as a substrate for the enzyme thymidylate kinase (TMPK) in the conversion of thymidine 5'-monophosphate (dTMP) to thymidine 5'-triphosphate (dTTP). This phosphorylation process necessitates ATP and Mg2+, making dTDP essential for nucleotide metabolism. Measurement of dTDP levels provides insight into TMPK activity and the regulation of DNA synthesis pathways, making it an important tool in biochemical research and studies of cell proliferation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	491-97-4
Applications	Pyrimidine Synthesis
Formula	C₁₀H₁₆N₂O₁₁P₂
Molecular Weight	402.19
Synonyms	dTDP
SMILES	O=C(N1)N([C@H]2C[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)C=C(C)C1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.