Thyroid hormone receptor antagonist (1-850)

Catalog No.: A85442
TR Antagonist
Thyroid hormone receptor antagonist (1-850) is a competitive and selective antagonist targeting thyroid hormone receptors (TR) with an IC50 of 1.5 μM. This compound effectively inhibits T3-mediated interactions between TRα and TRβ with nuclear receptor coactivators. Thyroid hormone receptor antagonist (1-850) is suitable for research focused on thyroid hormone signaling pathways and their implications in various biological processes, while exhibiting no effect on retinoic acid receptor alpha (RARα) activity.
Grouped product items
Size Price Stock Qty
5mg
$170.00
In stock
10mg
$295.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThyroid hormone receptor antagonist (1-850) is a competitive and selective antagonist targeting thyroid hormone receptors (TR) with an IC50 of 1.5 μM. This compound effectively inhibits T3-mediated interactions between TRα and TRβ with nuclear receptor coactivators. Thyroid hormone receptor antagonist (1-850) is suitable for research focused on thyroid hormone signaling pathways and their implications in various biological processes, while exhibiting no effect on retinoic acid receptor alpha (RARα) activity.
Product Information
Catalog NumA85442
FormulaC21H20F3N5O4
Molecular Weight463.41
CAS Number251310-57-3
SMILESO=C(NC1=CC(C(F)(F)F)=CC=C1)NNC(/C=C2CCN(CC\2)C3=CC=C(C=C3)[N+]([O-])=O)=O
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