Fig. 1 · Structure
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TIK-301
MT1/MT2 Receptors Agonist
TIK-301 (PD-6735) is a chlorinated derivative of melatonin that serves as a potent and selective agonist for the melatonin MT1 and MT2 receptors, exhibiting binding affinities of 0.081 nM and 0.042 nM, respectively. Additionally, TIK-301 functions as an antagonist for the 5-HT2B and 5-HT2C receptors, contributing to its antidepressant effects. This compound is primarily investigated for its therapeutic potential in sleep disorders and other circadian rhythm-related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 118702-11-7 |
| Applications | MT1/MT2 Receptors Agonist |
| Formula | C14H17ClN2O2 |
| Molecular Weight | 280.75 |
| Synonyms | PD-6735; LY-156735 |
| SMILES | CC(NC[C@@H](C1=CNC2=C1C=C(OC)C(Cl)=C2)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.