Tilisolol hydrochloride is a non-selective β-adrenergic antagonist that acts primarily on adrenergic receptors, demonstrating significant vasodilatory and hypotensive effects. This compound promotes relaxation of smooth muscle in canine coronary arteries through the opening of ATP-sensitive K+ channels and exhibits concentration-dependent relaxation in KCl-precontracted rat thoracic aorta. Additionally, tilisolol hydrochloride has been shown to reduce diastolic blood pressure in a dose-dependent manner, with a mild increase in heart rate observed in spinal cord-stimulated rats. It is widely used in cardiovascular research to study adrenergic signaling and blood pressure regulation.
Tilisolol hydrochloride is a non-selective β-adrenergic antagonist that acts primarily on adrenergic receptors, demonstrating significant vasodilatory and hypotensive effects. This compound promotes relaxation of smooth muscle in canine coronary arteries through the opening of ATP-sensitive K+ channels and exhibits concentration-dependent relaxation in KCl-precontracted rat thoracic aorta. Additionally, tilisolol hydrochloride has been shown to reduce diastolic blood pressure in a dose-dependent manner, with a mild increase in heart rate observed in spinal cord-stimulated rats. It is widely used in cardiovascular research to study adrenergic signaling and blood pressure regulation.
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