Tiospirone is a potent 5-HT2 receptor antagonist, demonstrating additional affinity for D2, 5-HT1A, 5-HT7, and sigma receptors. This compound has been shown to decrease ethanol consumption while enhancing food intake in rat models. Additionally, Tiospirone can diminish the reinforcing effects of cocaine, as evidenced in the conditioned place preference paradigm, making it a valuable tool for research into addiction and feeding behavior.
Tiospirone is a potent 5-HT2 receptor antagonist, demonstrating additional affinity for D2, 5-HT1A, 5-HT7, and sigma receptors. This compound has been shown to decrease ethanol consumption while enhancing food intake in rat models. Additionally, Tiospirone can diminish the reinforcing effects of cocaine, as evidenced in the conditioned place preference paradigm, making it a valuable tool for research into addiction and feeding behavior.
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