Tipifarnib (Zarnestra)

Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
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Size Price Stock Qty
1mg
$25.00
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2mg
$40.00
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5mg
$70.00
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10mg
$120.00
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25mg
$235.00
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50mg
$450.00
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100mg
$795.00
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10mM * 1mL in DMSO
$75.00
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Tipifarnib (Zarnestra) has been cited by 1 publications
  • Xiaoming Liu, .et al. , J Immunother Cancer, 2022, Apr;10(4):e004399 PMID: 35483745
  • Biological Activity
    Discription Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A10935
    Formula C27H22Cl2N4O
    Molecular Weight 489.4
    CAS Number 192185-72-1
    SMILES CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
    Synonyms IND 58359, R115777
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 14 mg/mL (28.6 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 15% Captisol+citrate vehicle 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.43 mL 102.17 mL 204.33 mL
    0.5 mM 4.09 mL 20.43 mL 40.87 mL
    1 mM 2.04 mL 10.22 mL 20.43 mL
    5 mM 0.41 mL 2.04 mL 4.09 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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