Tipifarnib (Zarnestra)

Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
Grouped product items
Product Name Price Stock Qty
Tipifarnib 5mg
$81.00
In stock
Tipifarnib 10mg
$144.00
In stock
Tipifarnib 25mg
$450.00
In stock
Tipifarnib 100mg
$800.00
In stock
Tipifarnib (Zarnestra) 10mM * 1mL in DMSO
$206.00
In stock
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Adooq Products cited in reputable paper
Adooq's Tipifarnib (Zarnestra) has been cited by 1 publications
  • Xiaoming Liu, .et al. , J Immunother Cancer, 2022, Apr;10(4):e004399 PMID: 35483745
  • Biological Activity
    Discription Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
    Targets
    Target Value
    Product Information
    Catalog Num A10935
    Formula C27H22Cl2N4O
    Molecular Weight 489.4
    CAS Number 192185-72-1
    SMILES CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
    Synonyms IND 58359, R115777
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 14 mg/mL (28.6 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 15% Captisol+citrate vehicle 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.43 mL 102.17 mL 204.33 mL
    0.5 mM 4.09 mL 20.43 mL 40.87 mL
    1 mM 2.04 mL 10.22 mL 20.43 mL
    5 mM 0.41 mL 2.04 mL 4.09 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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