Tipifarnib (Zarnestra)

Catalog No.: A10935

FTase inhibitor

Tipifarnib (Zarnestra) Chemical Structure

CAS NO. 192185-72-1

Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.

Availability: In stock

Package Price Qty
5 mg
$81.00
10 mg
$144.00
25 mg
$450.00
100 mg
$800.00
10mM * 1mL in DMSO
$206.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
Targets
FTase
0.6 nM
In vitro (25°C) DMSO 14 mg/mL (28.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol/citrate vehicle 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.43 mL 102.17 mL 204.33 mL
0.5 mM 4.09 mL 20.43 mL 40.87 mL
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

*The above data is based on the productmolecular weight 489.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10935
Actions Inhibitor
M. Wt 489.4
Formula C27H22Cl2N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 192185-72-1
Synonyms IND 58359, R115777
SMILES CN1C=NC=C1[[email protected]@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N

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