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- Xiaoming Liu, .et al. Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy, J Immunother Cancer, 2022, Apr;10(4):e004399 PMID: 35483745
Biological Activity
Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
Targets
FTase | ||||
0.6 nM |
In vitro (25°C) | DMSO | 14 mg/mL (28.6 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 15% Captisol+citrate vehicle | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.43 mL | 102.17 mL | 204.33 mL |
0.5 mM | 4.09 mL | 20.43 mL | 40.87 mL |
1 mM | 2.04 mL | 10.22 mL | 20.43 mL |
5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
*The above data is based on the productmolecular weight 489.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10935 |
---|---|
Actions | Inhibitor |
CAS No. | 192185-72-1 |
Formula | C27H22Cl2N4O |
M. Wt | 489.4 |
Purity | >98% |
Synonyms | IND 58359, R115777 |
SMILES | CN1C=NC=C1[[email protected]@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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