Tipifarnib (Zarnestra)

Name: Tipifarnib (Zarnestra)
Brand: Adooq Bioscience
SKU: A10935
Rating: 100 (268 reviews)

Catalog No.: A10935

FTase inhibitor

Tipifarnib (Zarnestra) Chemical Structure

CAS NO. 192185-72-1

Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.

Availability: In stock

Package	Price	Qty
5 mg	$81.00
10 mg	$144.00
25 mg	$450.00
100 mg	$800.00
10mM * 1mL in DMSO	$206.00
Custom Size	Get quote

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Biological Activity

Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.

Targets

FTase
0.6 nM

Solubility *

In vitro (25°C)	DMSO	14 mg/mL (28.6 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol+citrate vehicle	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.43 mL	102.17 mL	204.33 mL
0.5 mM	4.09 mL	20.43 mL	40.87 mL
1 mM	2.04 mL	10.22 mL	20.43 mL
5 mM	0.41 mL	2.04 mL	4.09 mL

*The above data is based on the productmolecular weight 489.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10935
Actions	Inhibitor
CAS No.	192185-72-1
Formula	C27H22Cl2N4O
M. Wt	489.4
Purity	>98%
Synonyms	IND 58359, R115777
SMILES	CN1C=NC=C1[[email protected]@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.