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TKA-731

NK1 Receptor Antagonist

TKA-731 is an NK1 receptor antagonist that effectively modulates nociceptive signaling. It has demonstrated the ability to reverse mechanical hyperalgesia and exhibit analgesic properties in neuropathic pain models, particularly in guinea pigs. This compound is valuable for research applications focused on understanding and targeting neuropathic pain mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	210776-01-5
Applications	NK1 Receptor Antagonist
Formula	C₃₅H₃₅N₅O₃
Molecular Weight	573.68
SMILES	O=C(N([C@H](C(N(C)CC1=CC=CC=C1)=O)CC2=CC=C(C=CC=C3)C3=C2)C)[C@H](CCC4)N4C5=NC(C6=CC=CC=C6N5)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.