TLR4-IN-1 is a selective TLR4 ligand inhibitor that effectively diminishes cell viability in RAW264.7 macrophages with an IC50 of 1.02 μM. This compound significantly reduces the release of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, demonstrating potent anti-inflammatory effects in models of rheumatoid arthritis in rats. Its targeted mechanism makes TLR4-IN-1 a valuable tool for studying the role of TLR4 in inflammatory processes and related therapeutic applications.
TLR4-IN-1 is a selective TLR4 ligand inhibitor that effectively diminishes cell viability in RAW264.7 macrophages with an IC50 of 1.02 μM. This compound significantly reduces the release of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, demonstrating potent anti-inflammatory effects in models of rheumatoid arthritis in rats. Its targeted mechanism makes TLR4-IN-1 a valuable tool for studying the role of TLR4 in inflammatory processes and related therapeutic applications.
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