TLR7/8 agonist 12

Catalog No.: A35424
Toll-like Receptor (TLR) Agonist
TLR7/8 Agonist 12 is a potent agonist for human Toll-like Receptors 7 and 8, exhibiting EC50 values of 11 nM and 150 nM, respectively. This compound is capable of immunomodulation, making it a valuable tool for researchers studying innate immune responses and developing therapeutic strategies for various diseases. Its ability to activate these receptors enhances the understanding of TLR-mediated signaling pathways in both basic and applied biomedical research.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTLR7/8 Agonist 12 is a potent agonist for human Toll-like Receptors 7 and 8, exhibiting EC50 values of 11 nM and 150 nM, respectively. This compound is capable of immunomodulation, making it a valuable tool for researchers studying innate immune responses and developing therapeutic strategies for various diseases. Its ability to activate these receptors enhances the understanding of TLR-mediated signaling pathways in both basic and applied biomedical research.
Product Information
Catalog NumA35424
FormulaC29H38N6O3
Molecular Weight518.65
CAS Number3080931-00-3
SMILESOCC[C@H](CCC)NC1=NC(N)=NC2=C1N(CC3=C(OC)C=CC(CN[C@@H]4COCC4)=C3)C5=C2C=CC=C5
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