TLR8 Agonist 7 is a potent agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It effectively stimulates the secretion of pro-inflammatory cytokine TNFα, exhibiting an EC50 of less than 1 μM. Additionally, TLR8 Agonist 7 demonstrates significant antitumor activity in an MC38-HER2 xenograft mouse model, achieving a tumor growth inhibition rate of 98%. This compound is valuable for research applications focusing on immune response modulation and cancer therapeutics.
TLR8 Agonist 7 is a potent agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It effectively stimulates the secretion of pro-inflammatory cytokine TNFα, exhibiting an EC50 of less than 1 μM. Additionally, TLR8 Agonist 7 demonstrates significant antitumor activity in an MC38-HER2 xenograft mouse model, achieving a tumor growth inhibition rate of 98%. This compound is valuable for research applications focusing on immune response modulation and cancer therapeutics.
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