TLR8 Agonist 8 (Compound II-72) acts as a potent agonist for Toll-like receptor 8 (TLR8), exhibiting an effective concentration (EC50) ranging from 0.25 to 1 μM. This compound is stable in both human and murine plasma and stimulates the secretion of cytokine TNFα, with an EC50 of less than 1 μM. Additionally, TLR8 Agonist 8 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89% in the MC38-HER2 xenograft mouse model, highlighting its potential for therapeutic applications in oncology and immunotherapy.
TLR8 Agonist 8 (Compound II-72) acts as a potent agonist for Toll-like receptor 8 (TLR8), exhibiting an effective concentration (EC50) ranging from 0.25 to 1 μM. This compound is stable in both human and murine plasma and stimulates the secretion of cytokine TNFα, with an EC50 of less than 1 μM. Additionally, TLR8 Agonist 8 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89% in the MC38-HER2 xenograft mouse model, highlighting its potential for therapeutic applications in oncology and immunotherapy.
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