TLR8 Agonist 9 (Compound II-77) is a selective agonist for Toll-like receptor 8 (TLR8), demonstrating an EC50 range of 0.25-1 μM. This compound effectively induces the secretion of the pro-inflammatory cytokine TNFα, with an EC50 of less than 1 μM. Additionally, TLR8 Agonist 9 exhibits significant antitumor activity in the MC38-HER2 xenograft mouse model, achieving a tumor growth inhibition (TGI) rate of 97%, making it a valuable tool for immunotherapy research and cancer studies.
TLR8 Agonist 9 (Compound II-77) is a selective agonist for Toll-like receptor 8 (TLR8), demonstrating an EC50 range of 0.25-1 μM. This compound effectively induces the secretion of the pro-inflammatory cytokine TNFα, with an EC50 of less than 1 μM. Additionally, TLR8 Agonist 9 exhibits significant antitumor activity in the MC38-HER2 xenograft mouse model, achieving a tumor growth inhibition (TGI) rate of 97%, making it a valuable tool for immunotherapy research and cancer studies.
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