Fig. 1 · Structure
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TMDJ-035
RyR2 Inhibitor
TMDJ-035 is a selective inhibitor of the Ryanodine Receptor 2 (RyR2), primarily targeting calcium release in cardiomyocytes. This compound effectively suppresses abnormal calcium waves and transients observed in isolated cardiomyocytes from RyR2-mutated mice. TMDJ-035 serves as a valuable reagent for investigating the mechanistic aspects and dynamics of RyR2 channel gating in cardiovascular research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2681302-83-8 |
| Applications | RyR2 Inhibitor |
| Formula | C16H12F3N5O |
| Molecular Weight | 347.29 |
| SMILES | FC1=CC(F)=CC(C2=NN(CC(N(C3=CC=C(F)C=C3)C)=O)N=N2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.