Target & Activity
| Target | Activity | Value |
|---|---|---|
| HDAC9 | IC50 | 9 nM |
| HDAC7 | IC50 | 46 nM |
| HDAC5 | IC50 | 106 nM |
| HDAC4 | IC50 | 111 nM |
| HDAC8 | IC50 | 11700 nM |
| HDAC6 | IC50 | 47800 nM |
6 targets · Scroll to view more
Fig. 1 · Structure
Documents & Downloads
TMP 195
Cat. No.
A14326
CAS
1314891-22-9
HDAC inhibitor
TMP195 is the most potent and selective class IIa HDAC inhibitor.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1314891-22-9 |
| Applications | HDAC inhibitor |
| Formula | C23H19F3N4O3 |
| Molecular Weight | 456.42 |
| SMILES | CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 79 mg/mL (173.08 mM) |
| Water | Insoluble |
| Ethanol | 79 mg/mL (173.08 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.