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Biological Activity
TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
| In vitro | DMSO | 89 mg/mL (172.97 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 2 mg/mL (3.88 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.44 mL | 97.18 mL | 194.36 mL |
| 0.5 mM | 3.89 mL | 19.44 mL | 38.87 mL |
| 1 mM | 1.94 mL | 9.72 mL | 19.44 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.89 mL |
*The above data is based on the productmolecular weight 514.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14128 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1314890-29-3 |
| Formula | C25H21F3N4O3S |
| M. Wt | 514.52 |
| Purity | >98% |
| Synonyms | TMP-269,TMP269 |
| SMILES | O=C(c1cccc(c1)c1noc(n1)C(F)(F)F)NCC1(CCOCC1)c1scc(n1)c1ccccc1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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