Fig. 1 · Structure
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TMP780
Cat. No.
A77591
CAS
1422053-03-9
RORγt Inverse Agonist
TMP780 is an inverse agonist of the nuclear receptor RORγt, demonstrating an IC50 value of 13 nM. This compound exhibits potential for modulating immune responses and inflammation, making it a valuable tool for research related to cutaneous inflammatory disorders. Its ability to inhibit RORγt activity positions TMP780 as a promising candidate for studies aimed at uncovering therapeutic strategies in inflammatory diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 1422053-03-9 |
| Applications | RORγt Inverse Agonist |
| Formula | C31H30N2O4 |
| Molecular Weight | 494.58 |
| SMILES | O=C(N[C@H](C1=CC=C(C)C=C1C)C2=CC=CC=C2)CC3=CC=C(OC([C@@H](C4=C(C)ON=C4C)O)=C5)C5=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.