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TNIK-IN-10

TNIK Inhibitor

TNIK-IN-10 is a potent inhibitor of TNIK, demonstrating an IC50 of 0.49 nM against human TNIK. By inhibiting TNIK enzymatic activity, it effectively downregulates Wnt pathway target genes such as c-Myc and AXIN2, while also reducing the protein expression levels of LRP5 and LRP6. Additionally, TNIK-IN-10 induces apoptotic processes and exhibits significant anticancer activity in colorectal cancer models, making it a valuable tool for research in colorectal cancer therapeutics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3112758-72-9
Applications	TNIK Inhibitor
Formula	C₂₈H₂₇N₅O₂
Molecular Weight	465.55
SMILES	CC(C)NCCN(CCO1)C(C(C1=C2)=CC=C2C3=CN=C(NC=C4C5=CC(C#N)=CC=C5)C4=C3)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.