Fig. 1 · Structure
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TNIK-IN-5
TNIK Inhibitor
TNIK-IN-5 is a potent inhibitor of TNIK, exhibiting an IC50 of 0.05 μM. This compound effectively disrupts Wnt signaling pathways in intact cells, making it a valuable tool for investigating the role of TNIK in cellular processes. TNIK-IN-5 demonstrates significant in vitro anti-colorectal cancer activity, supporting its potential utility in cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2754265-66-0 |
| Applications | TNIK Inhibitor |
| Formula | C22H17N3O3 |
| Molecular Weight | 371.39 |
| SMILES | O=C1OC2=CC(C3=CN=C(NC=C4)C4=C3)=CC=C2N1CC5=CC=CC(OC)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.