Tomatine hydrochloride is a glycoalkaloid derived from the tomato plant (Lycopersicon esculentum Mill.). It has been shown to induce neurotoxicity through mechanisms that are independent of RIP1 kinase and caspases, leading to the upregulation of nuclear apoptosis-inducing factor (AIF) in neuroblastoma cells. Additionally, tomatine hydrochloride inhibits 20S proteasome activity, making it a valuable reagent for research applications in cancer biology and neurodegeneration studies.
Tomatine hydrochloride is a glycoalkaloid derived from the tomato plant (Lycopersicon esculentum Mill.). It has been shown to induce neurotoxicity through mechanisms that are independent of RIP1 kinase and caspases, leading to the upregulation of nuclear apoptosis-inducing factor (AIF) in neuroblastoma cells. Additionally, tomatine hydrochloride inhibits 20S proteasome activity, making it a valuable reagent for research applications in cancer biology and neurodegeneration studies.
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