Tos-PEG4-t-butyl ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs. This compound plays a critical role in the development of targeted protein degraders, facilitating the design of molecules such as BI-3663, which selectively degrades protein tyrosine kinase 2 (PTK2) via cereblon-mediated E3 ligase recruitment. BI-3663 demonstrates significant inhibitory activity against PTK2, with an IC50 value of 18 nM, making Tos-PEG4-t-butyl ester a valuable reagent for research in targeted protein degradation and therapeutic applications.
Tos-PEG4-t-butyl ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs. This compound plays a critical role in the development of targeted protein degraders, facilitating the design of molecules such as BI-3663, which selectively degrades protein tyrosine kinase 2 (PTK2) via cereblon-mediated E3 ligase recruitment. BI-3663 demonstrates significant inhibitory activity against PTK2, with an IC50 value of 18 nM, making Tos-PEG4-t-butyl ester a valuable reagent for research in targeted protein degradation and therapeutic applications.
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