Fig. 1 · Structure
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Tos-PEG8-Tos
PROTAC Linkers
Tos-PEG8-Tos is a polyethylene glycol (PEG)-based linker specifically designed for the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligand moieties to E3 ligases, enabling targeted protein degradation. Its application in PROTAC synthesis supports studies in targeted therapy and cellular physiology, making it a valuable tool for researchers in drug discovery and development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 57436-38-1 |
| Applications | PROTAC Linkers |
| Formula | C30H46O13S2 |
| Molecular Weight | 678.81 |
| SMILES | O=S(C1=CC=C(C)C=C1)(OCCOCCOCCOCCOCCOCCOCCOCCOS(C2=CC=C(C)C=C2)(=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.