Fig. 1 · Structure
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TP-680
Cholecystokinin Receptor Antagonist
TP-680 is a potent cholecystokinin receptor antagonist, exhibiting a 1510-fold higher binding affinity for rat pancreatic CCKA receptors (IC50 = 1.2 nM) compared to rat brain CCKB receptors (IC50 = 1812.5 nM). This selectivity makes TP-680 a valuable tool for investigating gastrointestinal diseases. Its ability to modulate CCK receptor activity provides insights into gastrointestinal physiology and potential therapeutic applications in disorders related to CCK signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 176915-07-4 |
| Applications | Cholecystokinin Receptor Antagonist |
| Formula | C35H33N5O4S |
| Molecular Weight | 619.73 |
| SMILES | O=C(O)C1=CC=CN=C1SC[C@@H](C(N2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)=O)NC(C5=CC6=C(C=CC=C6)N5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.