Fig. 1 · Structure
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TPC2-A1-N
TPC2 Agonist
TPC2-A1-N is a potent agonist of the two-pore channel 2 (TPC2), functioning by mimicking the physiological effects of nicotinic acid adenine dinucleotide phosphate (NAADP). This compound elicits robust Ca2+ responses from TPC2 with an EC50 of 7.8 μM, an effect that can be inhibited by various TPC blockers. TPC2-A1-N serves as a valuable tool for investigating the distinct roles of TPC2 channels in cellular physiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 136186-07-7 |
| Applications | TPC2 Agonist |
| Formula | C17H9Cl2F3N2O2 |
| Molecular Weight | 401.17 |
| SMILES | O=C(NC1=CC=C(C(F)(F)F)C=C1)/C(C#N)=C(C2=CC(Cl)=CC(Cl)=C2)\O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.