Fig. 1 · Structure
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Trandolaprilate
ACE Inhibitor
Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor that functions by modulating the renin-angiotensin system. This compound effectively inhibits angiotensin-I-mediated c-fos induction, contributing to its pharmacological activities. As the principal bioactive metabolite of Trandolapril, Trandolaprilate exhibits high lipophilicity, making it relevant for various studies in cardiovascular research and hypertension management. Its use can facilitate investigations into the mechanisms of blood pressure regulation and the therapeutic potential in related cardiovascular conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 87679-71-8 |
| Applications | ACE Inhibitor |
| Formula | C22H30N2O5 |
| Molecular Weight | 402.48 |
| Synonyms | Trandolaprilat; RU 44403 |
| SMILES | O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.