Fig. 1 · Structure
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trans-ccc_R08
cccDNA Inhibitor
trans-ccc_R08 is a potent inhibitor of covalently closed circular DNA (cccDNA) with demonstrated anti-hepatitis B virus (HBV) activity. It exhibits IC50 values of 0.14 μM against HBeAg and 0.08 μM against HBsAg in vitro. This compound is valuable for research focused on hepatitis B virus infection and related applications, providing insights into potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2413192-49-9 |
| Applications | cccDNA Inhibitor |
| Formula | C22H19ClO6 |
| Molecular Weight | 414.84 |
| SMILES | O=C1C=C(C2=CC=C(C=C2)OCCO[C@@H]3C[C@H](C3)C(O)=O)OC4=C(Cl)C=CC=C41 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.