CFTR

Cat. No.

A66451

CAS No.

1613509-49-1

SRI-41315

SRI-41315 is a CFTR (cystic fibrosis transmembrane conductance regulator) activator that induces a prolonged pause at stop codons and suppresses premature termination codons (PTCs) associated with cystic fibrosis. This compound restores CFTR expression and function in both immortalized and primary human bronchial epithelial cells by decreasing the levels of the termination factor eRF1. Additionally, SRI-41315 enhances aminoglycoside-mediated readthrough, resulting in synergistic increases in CFTR activity, making it a valuable tool for research into cystic fibrosis and related therapies.

Cat. No.

A66468

CAS No.

2226970-01-8

CFTR corrector 6

CFTR Corrector 6 is a potent activator of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It is specifically designed for research into cystic fibrosis and other disorders associated with CFTR dysfunction. This compound enhances CFTR protein function, making it a valuable tool for investigating therapeutic strategies and understanding the underlying mechanisms of CFTR-related diseases.

Cat. No.

A66503

CAS No.

871700-29-7

CFTR activator 2

Synonyms: WAY-326769

CFTR Activator 2 (WAY-326769) is a selective activator of the cystic fibrosis transmembrane conductance regulator (CFTR), specifically targeting mutant forms of the protein. This compound enhances chloride ion transport across epithelial cell membranes, thereby improving ion permeability and function in cells expressing mutant CFTR. CFTR Activator 2 is valuable for research applications aimed at understanding cystic fibrosis pathophysiology and developing potential therapeutic strategies.