Sodium Channels | Adooq Bioscience

Cat. No.: A67005

CAS No.: 393845-92-6

SLC2A1 modulator-1

SLC2A1 modulator-1 is a selective modulator of the SLC2A1 transporter, which plays a crucial role in glucose transport and cellular metabolism. This compound has been shown to influence the uptake of glucose in various cell types, making it valuable for studying metabolic processes and diseases related to glucose dysregulation. Research applications include investigations into cancer metabolism, diabetes, and neurodegenerative disorders where SLC2A1 function may be altered.

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Cat. No.: A68156

CAS No.: 3004789-60-7

Nav1.8 modulator 1

Nav1.8 modulator 1 is a selective modulator targeting the Nav1.8 sodium channel, which plays a crucial role in the transmission of pain signals. This compound exhibits potent modulation properties, making it a valuable tool for pain research. Its ability to influence neuronal excitability can aid in the exploration of pain pathways and the development of novel analgesic therapies.

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Cat. No.: A68431

CAS No.: 2649467-91-2

Suzetrigine phenol

Suzetrigine phenol is a sodium channel modulator that acts by selectively altering the gating of sodium channels. This compound exhibits significant biological activity related to the modulation of neuronal excitability and has potential applications in the study of pain pathways and neuroprotection. Research utilizing Suzetrigine phenol can aid in understanding sodium channel function and developing therapeutic strategies for neurological disorders.

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1 mg

$400.00

5 mg

$820.00

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Cat. No.: A68486

CAS No.: 60748-45-0

ATX-II

ATX-II is a selective sodium channel modulator toxin that enhances late sodium current by preventing complete sodium channel inactivation, leading to persistent current fractions. This compound exhibits pro-arrhythmic effects, characterized by a slowed intrinsic heart rate, prolonged QT interval, and extended sinus node recovery time, potentially resulting in sinus pauses and arrests. ATX-II is valuable for research related to atrial fibrillation, long QT syndrome, and long QT3 syndrome.

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0.1 mg

$190.00

0.5 mg

$480.00

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Cat. No.: A68554

CAS No.: 135383-64-1

Clathrodin

Clathrodin is a marine alkaloid derived from Agelas sponges that functions as a modulator of voltage-gated sodium (NaV) channels. As a sodium channel neurotoxin, Clathrodin impacts sodium channel ionic conductance, making it a valuable tool for studying excitability in neurons and muscle cells. This reagent is useful in research applications involving neuropathic pain, neurotoxicity assessments, and the physiological characterization of sodium channel function.

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Cat. No.: A68663

CAS No.: 2153474-85-0

PF-05661014

PF-05661014 is a selective sodium channel modulator that primarily targets the Nav1.3 and Nav1.7 currents. By stabilizing inactivated channels through its interaction with the D4 voltage-sensor domain (VSD), PF-05661014 serves as an important tool in the study of sodium channel modulation. This reagent is valuable for research applications focused on understanding the role of sodium channels in various physiological and pathological processes.

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Cat. No.: A68672

CAS No.: 136565-76-9

Lamotrigine N2-Oxide

Lamotrigine N2-Oxide is a metabolite of the anticonvulsant agent Lamotrigine, targeting sodium channels to modulate neuronal excitability. This compound is primarily utilized in the study of epilepsy and related neurological disorders, providing insights into the pharmacological profiles of sodium channel modulators. Its role in research facilitates a better understanding of mechanisms underlying anticonvulsant activity and the potential development of novel therapeutic strategies.

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