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Voltage-Dependent Anion Channel (VDAC)

VDAC inhibitors act on voltage-dependent anion channels (VDAC), pores in the outer mitochondrial membrane. Three isoforms, VDAC1, VDAC2 and VDAC3, let ATP, ADP, metabolites and ions pass between the cytosol and mitochondria. VDAC1 also binds hexokinase and proteins of the B-cell lymphoma 2 (Bcl-2) family, which links the channel to apoptosis. In 2007, the small molecule erastin was found to cause oxidative cell death through VDAC2 and VDAC3, a process later named ferroptosis. VBIT-4 and VBIT-12 inhibit VDAC1, while WEHI-9625 and DIDS sodium salt are further channel inhibitors. The set is mixed: RSL3 targets glutathione peroxidase 4 (GPX4), and HK2-IN-4 inhibits hexokinase 2.

1 Item

  • SW016789
    Cat. No.
    A68924
    CAS No.
    292613-04-8

    SW016789

    SW016789 is a potent inducer targeting the voltage-dependent anion channel 1 (VDAC1). It effectively promotes insulin hypersecretion and enhances Ca2+ influx in pancreatic β-cells, leading to a transient endoplasmic reticulum (ER) stress response without inducing cell death. This compound exhibits reversible and non-apoptotic properties, making it a valuable tool for exploring β-cell dysfunction associated with type 2 diabetes mellitus (T2DM).

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    5 mg
    $165.00
    10 mg
    $270.00
    All 5 sizes

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