Fig. 1 · Structure
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Trihexyphenidyl hydrochloride
M1 Muscarinic Receptor Antagonist
Trihexyphenidyl hydrochloride is a selective antagonist of the M1 muscarinic receptor, exhibiting an IC50 of 3.7 nM in rat cerebral cortex M1 muscarinic receptors. This compound modulates cholinergic activity, effectively countering acetylcholine supersensitivity and providing therapeutic benefits in movement disorders. Additionally, Trihexyphenidyl hydrochloride has been shown to inhibit vagally-induced bradycardia, vasodilatation, and pressor responses stimulated by McN-A-343. It is a valuable tool for research applications related to Parkinson's disease and other cholinergic dysfunctions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 52-49-3 |
| Applications | M1 Muscarinic Receptor Antagonist |
| Formula | C20H32ClNO |
| Molecular Weight | 337.93 |
| SMILES | OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCCC3.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.