Fig. 1 · Structure
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Trimethoprim N-oxide
Human Urinary Metabolite
Trimethoprim N-oxide is a human urinary metabolite produced by the oxidation of nitrogen atoms within the pyrimidine ring of trimethoprim. The primary enzyme responsible for its formation is CYP1A2, predominantly active in human liver microsomes. This metabolite serves as an important biomarker for studies on drug metabolism and pharmacokinetics, particularly in understanding the effects of trimethoprim therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 27653-68-5 |
| Applications | Human Urinary Metabolite |
| Formula | C14H18N4O4 |
| Molecular Weight | 306.32 |
| Synonyms | Trimethoprim 1-N-oxide |
| SMILES | NC1=NC(N)=C(CC2=CC(OC)=C(OC)C(OC)=C2)C=[N+]1[O-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.