Fig. 1 · Structure
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Trimetrexate glucuronate
Dihydrofolate Reductase Inhibitor
Trimetrexate glucuronate is a potent inhibitor of dihydrofolate reductase, effectively functioning as a folic acid antagonist. By disrupting the synthesis of purine nucleotides and thymidylate, it significantly impairs DNA and RNA synthesis. This compound exhibits potential antitumor activity and is also applicable in the treatment and inhibition of Pneumocystis carinii pneumonia, making it a valuable tool in cancer research and infectious disease studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 82952-64-5 |
| Applications | Dihydrofolate Reductase Inhibitor |
| Formula | C25H33N5O10 |
| Molecular Weight | 563.56 |
| Synonyms | CI-898 glucuronate |
| SMILES | O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O.NC1=NC(N)=C2C(C)=C(CNC3=CC(OC)=C(OC)C(OC)=C3)C=CC2=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.