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TrimTAC1

Catalog No.: A40479
BRD4 PROTAC Degrader
TrimTAC1 is a TRIM21-based PROTAC designed to target BRD4 for selective degradation. This compound effectively promotes the degradation of NUP98FG-mEGFP-BRD4BD2 nuclear condensates without affecting soluble mEGFP-BRD4BD2 in A549 cells. TrimTAC1 is valuable for research applications aimed at studying the dynamics of protein degradation and the role of BRD4 in various cellular processes.
TrimTAC1 3095569-91-5 BRD4 PROTAC Degrader
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTrimTAC1 is a TRIM21-based PROTAC designed to target BRD4 for selective degradation. This compound effectively promotes the degradation of NUP98FG-mEGFP-BRD4BD2 nuclear condensates without affecting soluble mEGFP-BRD4BD2 in A549 cells. TrimTAC1 is valuable for research applications aimed at studying the dynamics of protein degradation and the role of BRD4 in various cellular processes.
Product Information
Catalog NumA40479
FormulaC43H47ClN8O2S2
Molecular Weight807.47
CAS Number3095569-91-5
SMILESO=C(NCCCN1CCN(CCCN2C(C=CC=C3)=C3SC4=C2C=C(C(C)=O)C=C4)CC1)C[C@H]5C6=NN=C(N6C7=C(C(C8=CC=C(C=C8)Cl)=N5)C(C)=C(S7)C)C
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    C2

    V2

Epigenetics > Epigenetic Reader Domain
PROTAC > PROTAC Degrader