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Trioxacarcin B

DNA Inhibitor

Trioxacarcin B is a potent DNA-targeting inhibitor known for its cytotoxic properties. It disrupts DNA function, leading to apoptosis in cancer cells while effectively inhibiting the growth of various Gram-positive and Gram-negative bacteria, as well as Plasmodium falciparum. Additionally, Trioxacarcin B diminishes colony formation of cancer stem cells and has demonstrated efficacy in reducing tumor volume and prolonging survival in preclinical in vivo models. The compound's activity relies on its intact spiro-epoxide structure, with hydrolysis leading to a loss of potency. Trioxacarcin B is applicable in research focusing on bacterial infections, malaria, and cancers such as colon cancer and melanoma.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	81534-36-3
Applications	DNA Inhibitor
Formula	C₄₂H₅₄O₂₁
Molecular Weight	894.87
Synonyms	TXN-B
SMILES	CC1=C(C(O2)=C3C(C(OC)=C4C(C([C@H](C[C@@H]4O[C@H]5C[C@@](O)([C@@H]([C@@H](O5)C)OC(C)=O)C)O)=O)=C3O)=C1)[C@@](O[C@]([C@]6(O)CO)(O7)C(OC)OC)([H])[C@@]7([H])[C@@]26O[C@H]8C[C@H]([C@](O)([C@@H](O8)C)C(C)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.