Fig. 1 · Structure
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TROX-1
Cav2.2 Inhibitor
TROX-1 is a selective inhibitor of the N-type calcium channel Cav2.2, demonstrating an IC50 value of 0.11 μM. This orally active compound exhibits state-dependent and use-dependent inhibition, specifically targeting open and inactivated channels to block depolarization-induced calcium influx. TROX-1 effectively reverses inflammatory-induced hyperalgesia and nerve injury-induced allodynia, making it a valuable tool in pain research. Its ability to penetrate the brain enhances its potential in studying central nervous system-related pain mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1309601-26-0 |
| Applications | Cav2.2 Inhibitor |
| Formula | C22H16ClFN6O |
| Molecular Weight | 434.85 |
| SMILES | O=C1N(C2=C([C@]1(CC3=CN=CN=C3)C)C=C(C=C2)C4=CC=C(C(Cl)=C4)F)C5=NNC=N5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.