TRPM5 agonist-1

Catalog No.: A68843
TRPM5 Agonist
TRPM5 agonist-1 is a potent TRPM5 agonist with a pEC50 of 8.1, demonstrating strong selectivity over related cation channels such as TRPM8, TRPV1, TRPV4, TRPA1, and TRPM4. This compound elicits a stimulatory effect on gastrointestinal transit in mouse models, making it valuable for studies focused on enhancing gastric motility. TRPM5 agonist-1 is suitable for research exploring the roles of TRPM5 in gastrointestinal physiology and motility regulation.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTRPM5 agonist-1 is a potent TRPM5 agonist with a pEC50 of 8.1, demonstrating strong selectivity over related cation channels such as TRPM8, TRPV1, TRPV4, TRPA1, and TRPM4. This compound elicits a stimulatory effect on gastrointestinal transit in mouse models, making it valuable for studies focused on enhancing gastric motility. TRPM5 agonist-1 is suitable for research exploring the roles of TRPM5 in gastrointestinal physiology and motility regulation.
Product Information
Catalog NumA68843
FormulaC11H7Cl2N3S2
Molecular Weight316.23
CAS Number2768029-03-2
SMILESClC1=CN=C(CNC2=CC3=C(C=C2Cl)C=NS3)S1
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