Fig. 1 · Structure
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TRPV1 antagonist 3
Cat. No.
A68727
CAS
2765294-54-8
TRPV1 Antagonist
TRPV1 antagonist 3 (Compound 7q) is a highly effective antagonist of the TRPV1 receptor, demonstrating an IC50 of 2.66 nM against capsaicin. This compound exhibits mode-selectivity and is characterized by favorable oral bioavailability (F = 60%) as well as the ability to penetrate the central nervous system. TRPV1 antagonist 3 is valuable for research focused on pain modulation and inflammatory processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2765294-54-8 |
| Applications | TRPV1 Antagonist |
| Formula | C23H25N3OS |
| Molecular Weight | 391.53 |
| SMILES | CC(C1=CC=CC(NC(N2CCC[C@H]2C3=NC=C(S3)C4=CC=CC=C4)=O)=C1)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.