TRPV1 antagonist 9 is a potent antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. It effectively inhibits calcium influx in Chinese hamster ovary (CHO) cells expressing TRPV1 receptors, with IC50 values of 0.6 nM for capsaicin and 0.8 nM for acid-induced calcium uptake. This compound has demonstrated the ability to block capsaicin-induced flinch responses and can induce hyperthermia in rat models, making it a valuable tool for exploring nociceptive pathways and pain mechanisms.
TRPV1 antagonist 9 is a potent antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. It effectively inhibits calcium influx in Chinese hamster ovary (CHO) cells expressing TRPV1 receptors, with IC50 values of 0.6 nM for capsaicin and 0.8 nM for acid-induced calcium uptake. This compound has demonstrated the ability to block capsaicin-induced flinch responses and can induce hyperthermia in rat models, making it a valuable tool for exploring nociceptive pathways and pain mechanisms.
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