Fig. 1 · Structure
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TRPV4 agonist-1 free base
Cat. No.
A68722
CAS
2314467-59-7
TRP Channel Agonist
TRPV4 agonist-1 free base is a selective agonist of the transient receptor potential vanilloid 4 (TRPV4) channel, demonstrating an EC50 of 60 nM in human TRPV4 calcium assays. This compound induces calcium influx and is instrumental in studies focused on the physiological roles of TRPV4 in nociception, osmoregulation, and cellular mechanotransduction. Research applications include investigating the channel's involvement in pain pathways and potential therapeutic targets for related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2314467-59-7 |
| Applications | TRP Channel Agonist |
| Formula | C25H22F2N4O2 |
| Molecular Weight | 448.46 |
| SMILES | O=C1N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C(N4CCN(C)CC4)=NC5=C(F)C=CC=C51 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.