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Trypanothione synthetase-IN-1

TryS Inhibitor

Trypanothione synthetase-IN-1 is a competitive inhibitor of trypanothione synthetase (TryS) in Leishmania infantum, exhibiting an IC50 of 14.8 μM when utilizing triamine spermidine as a polyamine substrate. This compound is valuable for studying the inhibition of TryS, providing insights into the metabolic processes of Leishmania and potential therapeutic strategies against leishmaniasis. Its specificity makes it a useful tool for researchers investigating trypanothione metabolism and the development of novel anti-parasitic agents.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2355349-41-4
Applications	TryS Inhibitor
Formula	C₄₀H₃₈F₃N₇O₅S
Molecular Weight	785.83
SMILES	[NH3+]CCCCC1=CN(C2=CC(OCCN3CCNC3=O)=C(C=C2)C4=NC(C5=CC=C(C=C5)OC6=CC=CC=C6)=C(C7=CC=CC=C7)S4)N=N1.O=C([O-])C(F)(F)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.