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Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.88 mL | 59.38 mL | 118.75 mL |
| 0.5 mM | 2.38 mL | 11.88 mL | 23.75 mL |
| 1 mM | 1.19 mL | 5.94 mL | 11.88 mL |
| 5 mM | 0.24 mL | 1.19 mL | 2.38 mL |
*The above data is based on the productmolecular weight 842.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18475 |
|---|---|
| M. Wt | 842.1 |
| Formula | C44H67N5O9S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1943604-24-7 |
| SMILES | O=C(O)[[email protected]@H](C)C[[email protected]@H](NC(C1=CSC([[email protected]](OC(C)=O)C[[email protected]@H](N(COC(CC(C)C)=O)C([[email protected]@H](NC([[email protected]@H]2N(C)CCCC2)=O)[[email protected]@H](C)CC)=O)C(C)C)=N1)=O)CC3=CC=C(C)C=C3 |
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