Tubulysin

Catalog No.: A18475

microtubule destabilizing agents

Tubulysin

Tubulysin Chemical Structure

CAS NO. 1943604-24-7

Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.88 mL 59.38 mL 118.75 mL
0.5 mM 2.38 mL 11.88 mL 23.75 mL
1 mM 1.19 mL 5.94 mL 11.88 mL
5 mM 0.24 mL 1.19 mL 2.38 mL

*The above data is based on the productmolecular weight 842.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18475
M. Wt 842.1
Formula C44H67N5O9S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1943604-24-7
SMILES O=C(O)[[email protected]@H](C)C[[email protected]@H](NC(C1=CSC([[email protected]](OC(C)=O)C[[email protected]@H](N(COC(CC(C)C)=O)C([[email protected]@H](NC([[email protected]@H]2N(C)CCCC2)=O)[[email protected]@H](C)CC)=O)C(C)C)=N1)=O)CC3=CC=C(C)C=C3

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Tubulysin | Tubulysin Supplier | purchase | cost | manufacturer | order | distributor | buy 1943604-24-7| 1943604-24-7 Supplier | purchase 1943604-24-7 | 1943604-24-7 cost | 1943604-24-7 manufacturer | order 1943604-24-7 | 1943604-24-7 distributor
Rewards