Fig. 1 · Structure
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Tunicamycin
ER Stress Inducer
Tunicamycin is an ER stress inducer that inhibits N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT). This action leads to the accumulation of unfolded proteins within the endoplasmic reticulum, resulting in ER stress, DNA synthesis inhibition, and G1 phase cell cycle arrest. Additionally, Tunicamycin exhibits antimicrobial activity against gram-positive bacteria, yeasts, fungi, and viruses while demonstrating anti-cancer potential. Notably, it also enhances exosome release in cervical cancer cells, making it valuable for research in cancer biology and cellular stress response pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 11089-65-9 |
| Applications | ER Stress Inducer |
| Formula | C39H64N4O16 |
| Molecular Weight | 844.94 (n=10) |
| SMILES | O=C1NC(N([C@H]2[C@H](O)[C@H](O)[C@@H](C(C[C@@H]3[C@H](O)[C@H](O)[C@@H](NC(/C=C/[(CH2) 8-11]C(C)C)=O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4NC(C)=O)O3)O)O2)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.