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TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression.
| In vitro | DMSO | 86 mg/mL (183.57 mM) | |
| Water | Insoluble | ||
| Ethanol | 46 mg/mL (98.19 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.35 mL | 106.73 mL | 213.46 mL |
| 0.5 mM | 4.27 mL | 21.35 mL | 42.69 mL |
| 1 mM | 2.13 mL | 10.67 mL | 21.35 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
*The above data is based on the productmolecular weight 468.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18829 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2097262-58-1 |
| Formula | C25H23F3N4O2 |
| M. Wt | 468.47 |
| Purity | >98% |
| Synonyms | TVB-3664; TVB 3664; TVB3664. |
| SMILES | CC1=C(C=C(C(C)=C1)C(N2CC(C2)C3=CC=C(C=C3)C#N)=O)C4=C(N=C(N4)C(F)(F)F)COC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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