Fig. 1 · Structure
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Type II topoisomerase inhibitor 1
DNA Gyrase Inhibitor
Type II topoisomerase inhibitor 1 is a selective inhibitor of E. coli DNA gyrase, exhibiting a potent inhibitory effect with an IC50 of 1.7 nM. This compound also inhibits topoisomerase IV activity, with an IC50 of 0.98 μM, through hydrogen bond interactions with the Asp73 residue. Type II topoisomerase inhibitor 1 serves as a valuable tool for research in the antibacterial field, facilitating studies on bacterial DNA replication and repair mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2245691-60-3 |
| Applications | DNA Gyrase Inhibitor |
| Formula | C18H15N3O4 |
| Molecular Weight | 337.33 |
| SMILES | CNC1=CC=CC2=C1NC(C(C(NC3=CC=C(C=C3)C(O)=O)=O)=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.