Fig. 1 · Structure
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UAWJ9-36-3
Mpro Inhibitor
UAWJ9-36-3 is a potent inhibitor of the main protease (Mpro) and cathepsin L, with an IC50 value of 1.81 μM. This compound exhibits strong binding affinity and enzymatic inhibition against Mpro from several coronaviruses, including SARS-CoV-2, SARS-CoV, MERS-CoV, and various human coronaviruses (HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1). UAWJ9-36-3 is a valuable tool for research aimed at developing therapeutic strategies against a range of coronavirus infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2663864-31-9 |
| Applications | Mpro Inhibitor |
| Formula | C23H29N3O5 |
| Molecular Weight | 427.49 |
| SMILES | O=C(NCC1)[C@@H]1C[C@@H](C=O)NC(C2[C@]3([H])[C@@](CN2C(OCC4=CC=CC=C4)=O)([H])C3(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.