Fig. 1 · Structure
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UCB-5307
TNF Inhibitor
UCB-5307 is a potent inhibitor of tumor necrosis factor (TNF) signaling, exhibiting a dissociation constant (KD) of 9 nM for human TNFα. This compound effectively disrupts the preformed human TNF/human TNF receptor 1 (hTNF/hTNFR1) complex, making it a valuable tool for investigating the role of TNF in various inflammatory and autoimmune conditions. UCB-5307 has significant potential for research applications aimed at understanding TNF-mediated pathways and developing therapeutic strategies targeting TNF signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1515887-44-1 |
| Applications | TNF Inhibitor |
| Formula | C22H21N3O |
| Molecular Weight | 343.42 |
| SMILES | OC(C1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2)C4=CC=NC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.