Fig. 1 · Structure
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UCB-6876
TNF Inhibitor
UCB-6876 is a selective inhibitor of TNFα, specifically binding to the asymmetric crystalline form of the TNF-α trimer with a KD of 22 μM. This compound exhibits key biological activity in modulating inflammatory responses and is relevant for research applications focused on autoimmune diseases such as rheumatoid arthritis and Crohn's disease. UCB-6876 offers valuable insights into TNFα-mediated pathways, facilitating the exploration of therapeutic strategies in chronic inflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 637324-45-9 |
| Applications | TNF Inhibitor |
| Formula | C17H18N2O |
| Molecular Weight | 266.34 |
| SMILES | OCC1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.