Fig. 1 · Structure
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UCB9386
Nuak1 Inhibitor
UCB9386 is a selective inhibitor of Nuak1, exhibiting strong brain penetration with an average pIC50 of 10.1. This compound also inhibits Nuak2 and Kak2, achieving approximately 50% inhibition at a concentration of 10 nM. UCB9386 is suitable for research applications involving metabolic regulation and neurobiology, providing valuable insight into the roles of AMP-activated protein kinases in cellular processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3096082-93-5 |
| Applications | Nuak1 Inhibitor |
| Formula | C27H26N8O |
| Molecular Weight | 478.55 |
| SMILES | C[C@H](C1=CC=CC=C1)N(C(C(N2CC3(CN(C)C3)C2)=N4)=O)C5=C4C=NC(C6=CN=C7C=CC=NN76)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.