Fig. 1 · Structure
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UKH-1114
σ2 Receptor/Tmem97 Agonist
UKH-1114 is a selective agonist for the sigma-2 receptor, specifically targeting TMEM97, with affinities of 1279 nM and 46 nM for σ1R and σ2R/TMEM97, respectively. This compound demonstrates remarkable selectivity, displaying minimal affinity for over 50 other receptors and ion channels. UKH-1114 has been shown to effectively alleviate mechanical hypersensitivity induced by spared nerve injury (SNI) while minimizing the risk of motor impairment. It serves as a valuable tool for investigating mechanisms of neuropathic pain.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2113664-14-3 |
| Applications | σ2 Receptor/Tmem97 Agonist |
| Formula | C22H24F3NO |
| Molecular Weight | 375.43 |
| SMILES | OCCCN1CCCC2C3=CC=C(C4=CC=C(C(F)(F)F)C=C4)C=C3C1C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.