Fig. 1 · Structure
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UP158
VCP Activator
UP158 is a potent valosin-containing protein (VCP) activator that enhances ATPase activity with an EC50 of 2.57 μM. This compound is valuable for research focused on cellular protein homeostasis and autophagy, as VCP plays a crucial role in the regulation of protein degradation pathways. UP158 may facilitate studies on the modulation of cellular processes involving protein unfolding and degradation, providing insights into various disease mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 489402-33-7 |
| Applications | VCP Activator |
| Formula | C17H17ClN4O2 |
| Molecular Weight | 344.80 |
| SMILES | ClC1=CC2=C(NC3=C(N4CCC5(CC4)OCCO5)N=CN=C32)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.